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La Fondation - die Gewinner

LA FONDATION LA ROCHE-POSAY

Communiqué

Three Up-and-Coming Researchers Who Represent the Future of Dermatology are Recognized at the European Academy of Dermatology & Venereology Annual Meeting in PARIS, September 13th, 2018

La Roche-Posay, announced the winners of the 23rd annual La Fondation La Roche-Posay European Research Awards 2018, which supports the work of outstanding candidates with promising projects in the field of clinical, biological and pharmacological research linked to dermatology. Since 1995 La Roche-Posay Foundation, which operates under the aegis of La Fondation de France, has been dedicated to the advancement of science for further research and dermatological innovations.

This year, three winners were chosen by the committee of La Fondation La Roche-Posay: the winners hails from UK, Austria and Germany.

  • Research Award of 25.000 €:
    Dr. Simon TSO of Human Metabolic Research Unit (HMRU), Coventry, for his project: "Erythroderma: exploration of changes in metabolism, appetite, hydration status and body composition"
  • Publication Award of 4.000 €:
    Dr. Ana Soler CARDONA of Skin and Endothelium Research Division (SERD), Department of Dermatology, Medical University Vienna, Austria for her publication: "CXCL5 facilitates melanoma cell-neutrophil interaction and lymph node metastasis"
    The Journal of Investigative Dermatology 10.1016/j.jid.2018.01.035
  • Publication Award of 4.000 €:
    Dr. Markus HEPPT of the Department of Dermatology and Allergy, University Hospital, LMU Munich (Germany) for his publication: "MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression"
    Journal of Investigative Dermatology (2018) 138, 141e149; doi:10.1016/j.jid.2017.05.038

Summary Dr. Markus HEPPT:
We have shown that the neural homeodomain transcription factor Msh homeobox 1 (MSX1) is expressed in melanoma and plays a pivotal role in the progression of the disease. Ectopic expression of MSX1 in primary (i.e. non-transformed) human melanocytes was sufficient to induce a reprogramming process towards a neural crest stem-like population. This de-differentiation was accompanied by altered cell morphology, a loss of pigmentation-related genes like MITF and tyrosinase, and a gain of the neural factors p75 nerve growth factor receptor (CD271) and L1CAM. In this state, the reprogrammed melanocytes could give rise to other cell lineages such as adipocytes, smooth muscle cells, or neuronal cells which we interpret as a state of multipotency induced by a single transcription factor. In melanoma, analyses of patient-derived tumor specimens and of publicly available TCGA RNA-Seq datasets revealed that there is a significantly increased expression of MSX1 in advanced disease stages. Strikingly, depletion of MSX1 strongly abrogated metastasis formation to the liver after tail vein injections of melanoma cells to immunodeficient NOD-scid IL2Rgammanull mice. Mechanistically, we have demonstrated that MSX1 overexpression went along with an increase of Wnt5a and ZEB1, two known drivers of epithelial-to-mesenchymal transition and cell invasion, but a decrease of MITF, a key regulator of a differentiated and pigmented phenotype. Taken together, these results imply that MSX1 may be a novel and pivotal factor in mediating melanoma heterogeneity, phenotype switching, and ultimately metastasis formation. This study substantially adds to a better and broader understanding of reprogramming and dedifferentiation processes in phenotype switching and disease progression of melanoma which may finally translate into better treatment decisions in this fatal type of skin cancer.

The winners were selected by La Fondation La Roche-Posay European Scientific Committee, which was comprised of academic leaders, including committee chairman Professor Mette Sondergaard DELEURAN (Aarhus University Hospital, Denmark), composed of

  • Professor Carlo GELMETTI (Unita Dermatologica Pediatrica Ospedale, Milano, Italy)
  • Professor Ramon GRIMALT (Universitat Internacional de Catalunya, Barcelona Spain)
  • Professor Branka MARINOVIC (University of Zagreb School of Medicine Zagreb Croatia)
  • Professor Eckart HANEKE (University of Berne, Switzerland)
  • Professor Alain TAIEB(CHU Bordeaux, France)
  • Professor Thomas BIEBER (University of Bonn, Germany)
  • Professor Waldemar PLACEK (University of Warmia and Mazury, Olsztyn, Poland)
  • Professor Pierre VABRES (CHU Dijon, France)
  • Professor Thomas LUGER (University of Muenster, Germany)
  • Dr. Veronique BATAILLE (Kings College London, UK)

The committee evaluated each of the submitted research proposals before naming Drs TSO, CARDONA and HEPPT as the most promising candidates.

“La Fondation La Roche-Posay helps to foster dermatology” said Prof. DELEURAN, the Chairman of the Awards Committee. “This is a great opportunity to support young researchers early in their careers. This year’s winners presented excellent research proposals and will now be better able to continue their great work. We congratulate each of them and will be excited to see the results of their research.”

LA FONDATION LA ROCHE-POSAY

Communiqué

La Roche-Posay announced the winners of the 22nd annual La Fondation La Roche-Posay European Research Awards 2017, which supports the work of outstanding candidates with promising projects in the field of clinical, biological and pharmacological research linked to dermatology.

This year, three winners were chosen by the committee of La Fondation La Roche-Posay: the winners hail from Germany, Spain and Austria.

  • Research Award of 25.000 €:
    Dr. Titus BRINKER, University Hospital Essen, Germany for his project: “Photoaging smartphone apps for skin cancer prevention in secondary school students: the Sunface randomized trial”
  • Publication Award of 4.000 €:
    Dr. Simone RIBERO, Hospital Clinic University of Barcelona, Spain for his publication: “Acne and Telomere Length: A New Spectrum Between Senescence and Apoptosis Pathways”
    Journal of Investigative Dermatology 2016 Sep 28. doi: 10.1016/j.jid.2016.09.014.
  • Publication Award of 4.000 €:
    Dr. Robert GRUBER, Department of Dermatology, Venereology and Allergology, Innsbruck, Austria was given the Publication Award for his publication: “Autosomal recessive Keratoderma-Ichthyosis-Deafness (ARKID) syndrome is caused by VPS33B mutations affecting Rab protein interaction and collagen modification”
    Journal of Investigative Dermatology. doi: 10.1016/j.jid.2016.12.010

The Scientific Committee, chaired by Professor Carlo GELMETTI (Italy), composed of

  • Professor Ramon GRIMALT (Spain)
  • Professor Linda de RAEVE (Belgium)
  • Professor Eckart HANEKE (Switzerland)
  • Professor Alain TAIEB (France)
  • Professor Thomas BIEBER (Germany)
  • Professor Waldemar PLACEK (Poland)
  • Professor Mette Søndergaard DELEURAN (Denmark)
  • Professor Pierre VABRES (France)
  • Professor Thomas LUGER (Germany)
  • Dr. Veronique BATAILLE (UK)

The committee evaluated each of the submitted research proposals before naming Drs. BRINKER, RIBERO and GRUBER as the most promising candidates.

“La Fondation La Roche-Posay helps to foster dermatology.” said Prof. Gelmetti, the Chairman of the Awards Committee. “This is a great opportunity to support young researchers early in their careers. This year’s winners presented excellent research proposals and will now be better able to continue their great work. We congratulate each of them and will be excited to see the results of their research.”

Dr. Titus BRINKER of University Hospital Essen, Germany was given the Research Award for his project: “Photoaging smartphone apps for skin cancer prevention in secondary school students: the Sunface randomized trial”

“According to the World Health Organization, the incidence of melanoma is increasing faster than any other major cancer world wide. A main risk factor for developing melanoma is exposure to UV radiation (UVR) by natural sun exposure and sunbeds which are increasing in popularity. Attractiveness is the main motivation for unhealthy tanning behavior in young target groups. An intervention that takes advantage of the broad availability of mobile phones as well as adolescents’ interest in their appearance may be a novel and cost-effective way to improve prevention. In the planned randomized trial, we aim to use mobile phone technology to measure the effectiveness of an educational photoaging app to prevent sun-induced skin damage in the vulnerable target group of adolescents at the age of 14-18 years by the help of our free photoaging mobile app “Sunface”: The app will be implemented in at least 60 secondary school classes in February 2018 via a novel method called mirroring. The students’ altered three-dimensional selfies on mobile phones or tablets are “mirrored” via a projector in front of their whole grade showing the effects of UV exposure on their own future faces. UV protection behavior, its predictors and app-use are measured via a pseudomized paper pencil questionnaire before, directly after and six months post-intervention. In addition to sociodemographic data, skin type, ancestry, UV protection behavior and its predictors are measured via a paper-pencil questionnaire before, three and six months post-intervention. The primary endpoint is the difference in the 30-day-prevalence of daily sunscreen use between both groups at six months follow-up. Secondary endpoints include the difference of daily sunscreen use at three months follow-up, if a self-skin exam in accordance with the ABCDE rule was performed within the six months follow-up and other measures of sun protection behavior. The research grant for young researchers enables us to run the first randomized trial globally to measure the effectiveness of a photoaging intervention to prevent unhealthy tanning behavior. The app will be translated in the six most spoken languages to allow free use by health educators, risk groups and researchers worldwide.”

LA FONDATION LA ROCHE-POSAY

Communiqué

La Roche-Posay announced the winners of the 21th annual La Fondation La Roche-Posay European Research Awards 2016, which supports the work of outstanding candidates with promising projects in the field of clinical, biological and pharmacological research linked to dermatology.

This year, three winners were chosen by the committee of La Fondation La Roche-Posay: the winners hails from France, Spain and Germany.

  • Research Award of 25.000 €:
    Dr. Charlotte HURABIELLE, Hôpital St Louis, Paris, for her project: “Interactions of innate cells with microbiota in the pathogenesis of cutaneous Inflammatory conditions: study on psoriasis”
  • Publication Award of 4.000 €:
    Dr. Carla FERRANDIZ PULLIDO, University Hospital Val d'Herbron, Barcelona, for her publication: “Identification of somatic gene mutations in penile squamous cell carcinoma"
    Genes, Chromosomes et Cancer, May 2015, doi: 10.1002.
  • Publication Award of 4.000 €:
    Dr. Ingo STOFFELS, University Hospital Essen, for his publication: “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multisprectral optoacoustic imaging”
    Science Translational Medicine, dec 2015, vol 7, issue 317ra199.

The Scientific Committee chaired by Professor Carlo GELMETTI (Italy) and composed of

  • Professor Ramon GRIMALT (Spain)
  • Professor Linda de RAEVE (Belgium)
  • Professor Eckart HANEKE (Switzerland)
  • Professor Alain TAIEB (France)
  • Professor Thomas BIEBER (Germany)
  • Professor Waldemar PLACEK (Poland)
  • Professor Mette Søndergaard DELEURAN (Denmark)
  • Professor Pierre VABRES (France)
  • Professor Veronique BATAILLE (UK)
  • Professor Thomas LUGER (Germany)

Dr. Charlotte HURABIELLE of Hôpital St Louis, Paris was given the Research Award for her project: “Interactions of innate cells with microbiota in the pathogenesis of cutaneous Inflammatory conditions: study on psoriasis”.

“There are growing evidences that gut and skin microbiota plays a key role in the regulation of inflammation. Recently discovered cells named innate lymphoid cells (ILCs) are increased in blood and skin of psoriasis patients, a common chronic inflammatory skin disease in which patients suffer from a significant impairment of quality of life and have an increased risk of further development of other severe pathologies such as depression, psoriatic arthritis or cardiovascular complications. It seems that some bacteria may transmit signals regulating the activation of ILCs, especially leading ILCs in turn to product pro-inflammatory signals. With this award, we will define the response of ILCs to commensal bacteria in inflammatory psoriatic skin versus in normal skin: to this aim, we will perform co-cultures of ILCs with bacterial extracts of psoriatic and healthy skin, as well as with a recently discovered disease-relevant bacterium that is currently grown in the host laboratory. We will then study how ILCs lead other inflammatory cells to trigger psoriatic skin inflammation, and the association between the presences of specific skin bacteria with the onset of the disease. Finally, we will validate the role of ILCs in humanized models of psoriasis.”

Dr. Carla FERRANDIZ PULLIDO of the University Hospital Val d'Herbron, Barcelona, was given the Publication Award for her publication: "Identification of somatic gene mutations in penile squamous cell carcinoma" published in Genes, Chromosomes et Cancer, May 2015, doi: 10.1002”.

“Este premio es una gran satisfacción y representa un reconocimiento al esfuerzo realizado durante los últimos años, que en última instancia es para el beneficio del paciente. Además es un reflejo de los buenos resultados del trabajo multidisciplicar; en este caso se han implicado especialistas de Dermatología, Patología, Urología y Oncologia.”

Dr. Ingo STOFFELS of the University Hospital Essen, was given the Publication Award for his publication: "Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multisprectral optoacoustic imaging" published in Science Translational Medicine, dec 2015, vol 7, issue 317ra199”.

“Sentinel lymph node excision is included in current AJCC guidelines of various cancers and represents the current gold standard of identifying microscopic metastatic disease in draining lymph nodes. Although very effective, SLN excision does have its drawbacks as it requires radioactive tracers, is rather costly, creates a diagnostic delay and has the potential for surgical morbidity. Novel noninvasive approaches excluding the presence of lymph node metastasis, could allow the majority of patients to avoid SLN excision. By awarding scientific research the “La Fondation La Roche-Posay” supports innovative work dedicated to improve patient diagnostics and treatment in the field of dermato-oncology. In the awarded work we present data analyzing over 500 sentinel lymph nodes with an imaging technique called multispectral optoacoustic tomography (MSOT). MSOT identified cancer-free SLNs in vivo and ex vivo without a single false negative, with 100% sensitivity and 48 to 62% specificity. Our findings indicate that a noninvasive, nonradioactive MSOT-based approach can identify and determine SLN status and confidently rule out the presence of metastasis.”

FONDATION INTERNATIONALE LA ROCHE-POSAY 2015

Communiqué

This year, the Foundation's jury members reviewed 43 works: 17 for the research project grant of 25.000 €, and 26 for the two publications grants of 4.000 € each. During the 24th EADV congress in Copenhagen, on October 8th, the jury members of "La Fondation La Roche-Posay" were gathered to nominate the winners.

Three applicants have been awarded by the jury:

  • Research Award of 25.000 €:
    Ludovic WROBEL, Department of Dermatopathology, University Hospital Geneva, for his project: “Influence of environmental stress on anti-tumor immunity”
  • Publication Award of 4.000 €:
    Emmanuella GUENOVA, University of Zurich, Department of Dermatology, for her publication: “IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells" Proc Natl Acad Sci USA. 2015 Feb 17; 112(7): 2163–2168.
  • Publication Award of 4.000 €:
    Andrew James MUINONEN-MARTIN, York, teaching Hospital NHS Foundation Trust, for his publication: “Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal” PLoS Biol. 2014 Oct; 12(10): e1001966

The Scientific Committee chaired by Professor Gelmetti (Italy) and composed of

  • Professor Deleuran (Denmark)
  • Professor de Raeve (Belgium)
  • Professor Taieb and Professor Vabres (France)
  • Professor Bieber, Professor Haneke and Professor Luger (Germany)
  • Professor Placek (Poland)
  • Professor Grimalt (Spain)
  • Professor Bataille (UK)

FONDATION INTERNATIONALE LA ROCHE-POSAY 2014

Communiqué

This year, the Foundation's jury members reviewed 45 works: 27 for the research project grant of 25 000€, and 18 for the 2 publications grants of 4 000€ each.

The Scientific Committee chaired by Pr GELMETTI (Italy) and composed of Pr DELEURAN (Denmark)

  • Pr De RAEVE (Belgium)
  • Pr TAIEB and Pr VABRES (France)
  • Pr BIEBER, Pr HANEKE and Pr LUGER (Germany)
  • Pr PLACEK (Poland)
  • Pr GRIMALT (Spain)
  • Pr BATAILLE (UK)

decided to award:

  • The Research Project Prize of 25 000€
    To Maria GNARRA, University of Parma, Italy, Department of Dermatology For the project “Infantile Haemangiomas: in vivo study of the microvascular environment”
  • 1st Publication Prize of 4 000€
    To Martina GATZKA, University of Ulm, Germany, Department of Dermatology “Reduction of CD18 promotes expansion of inflammatory γδ T cells collaborating with CD4+ T cells in chronic murine psoriasiform dermatitis”
    J Immunol. 2013 Dec 1;191(11):5477-88 martina gatzka
  • 2nd Publication Prize of 4 000€
    To Peter Arne GERBER, University of Duesseldorf, Germany, Department of Dermatology “Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins”
    PLoS One. 2013 Jun 20;8(6):e63949
Martina GATZKA

FONDATION INTERNATIONALE LA ROCHE-POSAY 2013
Communiqué

During the 22nd EADV congress in Istanbul, on October 3rd the jury members of the "Fondation La Roche-Posay" were gathered to nominate the winners.

The purpose of this foundation established in 1995, is to encourage and reward international research works in Dermatology. This year, the Foundation’s jury reviewed 40 works: 20 for the research prize of 20 000€, and 20 for the 2 publication prizes of 4.000€ each.

The Scientific Committee chaired by Pr GELMETTI (Italy) and composed of

  • Pr DELEURAN (Denmark)
  • Pr De RAEVE (Belgium)
  • Dr BATAILLE (UK)
  • Pr GRIMALT (Spain)
  • Pr HANEKE, Pr BIEBER and Pr LUGER (Germany)
  • Pr PLACEK (Poland)
  • Pr TAIEB and Pr VABRES (France)

decided to award :

  • The Research Project Prize of 20 000€
    To Ni Xu LANDEN, Karolinska Institutet, Department of Medicine, Unit of Dermatology, Stockholm Sweden

    "Investigation of the Role of MicroRNAs in Skin Wound Healing"
  • 1st Publication Prize of 4 000€
    To Wolfram HÖTZENECKER, Department of Dermatology, University of Zürich Switzerland

    "ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression"
    Nature Medicine 2011 18;18(1) : 128-34
  • 2nd Publication Prize of 4 000€
    To Jana KNUEVER, Department of Dermatology, University Hospital of Cologne Germany

    "Thyrotropin-Releasing Hormone Controls Mitochondrial Biology in Human Epidermis"
    Journal of Clinical Endocrinology and Metabolism (JCEM) March 2012, 97:978-986

FONDATION INTERNATIONALE LA ROCHE-POSAY 2012
Communiqué

During the 21st EADV congress in Prague, on September 28th the jury members of the "Fondation Internationale La Roche-Posay" were gathered to nominate the winners.

The purpose of this foundation established in 1995, is to encourage and reward international research works in Dermatology. This year, the Foundation's jury reviewed 25 works: 13 for the research prize of 20.000 €, and 12 for the 2 publication prizes of 4.000 € each.

The Scientific Committee chaired by Pr BIEBER (Germany) and composed of

  • Pr DELEURAN (Denmark)
  • Pr De RAEVE (Belgium)
  • Pr GELMETTI (Italy)
  • Pr GRIMALT (Spain)
  • Pr HANEKE and Pr LUGER (Germany)
  • Pr PLACEK (Poland)
  • Pr TAIEB and Pr VABRES (France)

decided to award :

  • The Research Project grant of 20.000 €
    To Claudia GÜNTHER, Universitätsklinikum Carl Gustav Carus DRESDEN , Klinik für Dermatologie "Defects in DNA replication and DNA repair in the pathogenesis of lupus erythematosus"
  • 1st Publication grant of 4.000 €
    To Julien SENESCHAL, Université De BORDEAUX, Hôpital Saint André, Department of Dermatology

    "Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activatin Skin Resident Regulatory T Cells"
    Published in Immunity 36,1-12,May,2012
  • 2nd Publication grant of 4.000 €
    To Dimitra KIRITSI, University of FREIBURG, Department of Dermatology

    "Revertant mosaicism in a human skin fragility disorder results from slipped mispairing and mitotic recombination"
    J Clin Invest. 2012 May 1;122(5):1742-6. doi: 10.1172/JCI61976. Epub 2012 Apr 2.

FONDATION INTERNATIONALE LA ROCHE-POSAY
COMMUNIQUÉ

During the 20th EADV congress in LISBON, on October 21st the jury members of the "Fondation Internationale La Roche-Posay" were gathered to nominate the winners.

The purpose of this foundation established in 1995, is to encourage and reward international research works in Dermatology. This year, the Foundation's jury reviewed 22 works: 7 for the research prize of 20 000 €, and 15 for the 2 publication prizes of 4.000 € each.

The Scientific Committee chaired by Pr BIEBER (Germany) and composed of

  • Pr DELEURAN (Denmark)
  • Pr De RAEVE (Belgium)
  • Pr GELMETTI (Italy)
  • Pr GRIMALT (Spain)
  • Pr HANEKE and Pr LUGER (Germany)
  • Pr GAWKRODGER (U.K)
  • Pr PLACEK (Poland)
  • Pr TAIEB and Pr VABRES (France)

decided to award :

  • THE RESEARCH PROJECT PRIZE OF 20 000 € :
    To Elisabetta BOTTI, Department of Dermatology, University "Tor Vergata", ROMA Italy,

    "Modulating Melanoma Invasive Status by Histone Deacetylase inhibitors"
  • 1ST PUBLICATION PRIZE OF 4.000 €
    To Matthieu LACROIX, IRCM, Inserm U896, MONTPELLIER, France

    "Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis"
    Published in PNAS, December 2010/ Vol 107/n° 49
  • 2ND PUBLICATION PRIZE OF 4.000 €
    This year, due to 2 ex-aequo applications, the jury decided to split the 4.000€ amount in 2 equal amounts of 2.000€.
  • 2.000 € to Felix WEBER, Department of Dermatology,
    University Medical Center, FREIBURG, Germany

    "Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity"Published in J.Exp.Med, November 2010 207(12):2609-2619
  • 2.000 € to Prof. Dr. med. Christian Hafner, Department
    of Dermatology, University of Regensburg , REGENSBURG, Germany "Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors"
    Published in PNAS, November 2010/vol 107/n°48

FONDATION INTERNATIONALE LA ROCHE-POSAY
Communiqué

During the 19th EADV congress in Gothenburg, on October 7th the jury members of the „Fondation Internationale La Roche-Posay” were gathered to nominate the winners.

The purpose of this foundation established in 1995, is to encourage and reward international research works in Dermatology. This year, the Foundation™s jury reviewed 35 works: 9 for the research prize of 20 000 €, and 26 for the 2 publication prizes of 4.000 Euro each.

This year, the Foundation’s jury reviewed 36 works: 12 for the research prize of 20 000 Euro, and 14 for the 2 publication prizes of 4.000 Euro each.

The Scientific Committee chaired by Pr BIEBER (Germany) and composed of Pr DELEURAN (Denmark), Pr De RAEVE (Belgium), Pr GELMETTI (Italy), Pr GRIMALT (Spain), Pr HANEKE (Germany), Pr LUGER (Germany), Pr PLACEK (Poland), Pr TAIEB (France) and Pr VABRES (France), decided to award:

  • The Research Project Prize of 20 000 Euro:
    To Karin Stenderup, Service of Dermatology, University Hospital, Aarhus, Denmark

    „The Role of Protein Kinase C in Psoriasis and other Inflammatory Skin Diseases”
  • The Publication Prize of 4 000 Euro:
    To Karin Loser, Universitätsklinikum Münster Klinik and Poliklinik of Dermatology, Münster, Germany

    "The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells"
    Accepted for publication by Nature Medicine April 2010 PD Dr. Karin Loser
  • The Publication Prize of 4 000 Euro:
    To Céline Deraison, Department of Genetic Skin Disease, Hopital Purpan Toulouse, France

    "KLK5 induces atopic dermatitis-like lesions through PAR2-mediated and TSLP overexpression in Netherton Syndrome"
    Journal of Experimental Medicine, 2009, 206(5): 1135-1147

FONDATION INTERNATIONALE LA ROCHE-POSAY
Communiqué

During the 18th EADV congress in Berlin, on October 9th the jury members of the „Fondation Internationale La Roche-Posay” were gathered to nominate the winners.

The purpose of this foundation established in 1995, is to encourage and reward international research works in Dermatology. This year, the Foundation™s jury reviewed 37 works: 13 for the research prize of 20 000 Euro, and 24 for the 2 publication prizes of 4.000 Euro each.

This year, the Foundation’s jury reviewed 36 works: 12 for the research prize of 20 000 Euro, and 14 for the 2 publication prizes of 4.000 Euro each.

The Scientific Committee chaired by Pr BIEBER (Germany) and composed of Pr de RAEVE (Belgium), Pr GELMETTI (Italy), Pr GRIMALT (Spain), Pr HANEKE and Pr LUGER (Germany), Pr McGRATH (England), Pr PANIZZON (Switzerland), Pr PLACEK ( Poland), Pr TAIEB and Pr VABRES (France) decided to award:

  • The Research Project Prize of 20 000 Euro:
    To Dr Jurgen Schauber, Klinik und Poliklinic für Dermatology und Allergology, klinikum der Universität Munchen, Germany
    „Balancing 'alarmin' expression: a novel approach to treatment of inflammtory skin diseases”
  • The Publication Prize of 4 000 Euro:
    To Dr Dr Nora Belso, Department of Dermatology and Allergology, University of Szeged, Hungary

    „Differential Expression of D-Type Cyclins in HaCat Keratinocytes and in Psoriasis".
    Jounal of Investigative Dermatology 2008, vol 128, 634-642
  • The Publication Prize of 4 000 Euro:
    To Dr Ulf Meyer-Hoffert, Klinik für Dermatology, Venerology und Allergology, Universitätklinikum, Kiel , Germany

    „Identification of lympho-epithelial Kazal-tyupe inhibitor 2 in human skin as a Kallikrein-related peptidase 5-specific protease inhibitor”
    PLoS ONE 2009 Vol4, issue 2, e4372

 

FONDATION INTERNATIONALE LA ROCHE-POSAY
Communiqué

During the last congress „European Academy of Dermatology and Venereology” in Paris, the jury members of the „Fondation Internationale La Roche-Posay” were gathered to nominate the winners for the Year 2008.

The purpose of this foundation established in 1995, is to encourage and reward international research works in Dermatology.

This year, the Foundation’s jury reviewed 36 works: 12 for the research prize of 20 000 Euro, and 14 for the 2 publication prizes of 4.000 Euro each.

The Scientific Committee chaired by Pr BIEBER (Germany) and composed of Pr de RAEVE (Belgium), Pr GELMETTI (Italy), Pr GRIMALT (Spain), Pr HANEKE and Pr LUGER (Germany), Pr McGRATH (England), Pr PANIZZON (Switzerland), Pr PLACEK ( Poland), Pr TAIEB and Pr VABRES (France) decided to award:

  • The Research Project Prize of 20 000 Euro:
    To Dr Christine Labreze, Dept of Dermatology paediatric, University Hospital of Bordeaux, France

    „Beta adrenergic signalling in infantile haemangioma”
  • The Research Prize of 4 000 Euro for already published research paper:
    To Dr Günther Weindl, Institute of Pharmacy, Pharmacology and Toxicology, Freie Universitat Berlin, Germany

    „Human epithelial cells establish direct antifungal defence through TLR4-mediated signalling".
    Journal of Clinical Investigation, vol117, N12, Dec 007
  • The Research Prize of 4 000 Euro for already published research paper:
    To Dr Annabel Maruani, Department of Dermatology, Hospital CHRU Trousseau, Tours, France

    „Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows to predict its outcome”
    American journal of Clinical Pathology, Feb. 2008

FONDATION INTERNATIONALE LA ROCHE-POSAY
Communiqué

During the last congress „European Academy of Dermatology and Venereology” in Vienna the jury members of the „Fondation Internationale La Roche-Posay” were gathered to nominate the winners for the Year 2007.

The purpose of this foundation established in 1985, is to encourage and reward international research works in Dermatology.

This year, the Foundation’s jury reviewed 30 works: 14 for the research prize of 20 000 Euro, and 16 for the 2 publication prizes of 4.000 Euro each.

The Scientific Committee chaired by Pr TAIEB (France) and composed of Pr GELMETTI (Italy), Pr HANEKE (Germany), Pr de RAEVE (Belgium), Pr GRIMALT (Spain), Pr BLACK (England), Pr LARREGUE (France), Pr BIEBER (Germany) Pr LUGER (Germany),Pr PLACEK ( Poland) and Pr PANIZZON (Switzerland) decided to award :

  • The Research Project Prize of 20 000 Euro:
    To Prof. Mark Berneburg and Dr. Winfried Schuller,
    Dept of Dermatology, University of Tübingen, Germany

     „The role of the Warburg effect in UV-induced progression of malignant melanoma”
  • The Research Prize of 4 000 Euro for already published research paper:
    To Dr Wioletta Baranska-Rybak,
     Department of Dermatology, University of Gdansk, Poland

    „Glycosaminoglycans inhibit the antibacterial action of LL-37 in biological fluids".
  • The Research Prize of 4 000 Euro for already published clinical study paper:
    To Prof. Hjalmar Kurzen, Department of Dermatology, Venerology and Allergology, Medical Faculty Mannheim, Germany

    „Functional characterization of the epidermal cholinergic system in vitro”

Die Preise der Fondation International LA ROCHE-POSAY Laboratoire Dermatologique 2006

wurden im Rahmen des Kongresses der EADV (European Academy of Dermatology and Venerologie) in Rhodos vergeben

In diesem Jahr hat das internationale wissenschaftliche Komitee unter dem Vorsitz von Prof. TAIEB (Frankreich) und den Mitgliedern Prof. GELMETTI (Italien), Prof. HANEKE (Deutschland), Prof. de RAEVE (Belgien), Prof. GRIMALT (Spanien), Prof. BLACK (England), Pr LARREGUE (Frankreich), Prof. BIEBER (Deutschland), Prof. LUGER (Deutschland), Prof. PLACEK (Polen) und Prof. PANIZZON (Schweiz)

3 Forscher für ihre Arbeit in der dermatologischen Forschung ausgezeichnet:

  • The Research Project Prize of 20 000 Euro : an Herrn Dr. med. Axel Roers, Universitäts-Hautklinik Köln
    „T-Cell-mediated dermal inflammation: model for skin fibrosis in systemic sclerosis”
  • The Research Prize of 4 000 Euro for already published research paper an Alan Irvine, Department of Pediatric Dermatology, Our Lady´s Hospital for Sick Children, Dublin, Ireland

    „Common loss-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis”
  • The Research Prize of 4 000 Euro for already published clinical study paper an
    Frau Dr. med. Annika Vogt,
    Universitäts-Hautklinik Leipzig

    „40 nm, but not 750 or 1.500 nm, nanoparticules enter epidermal CD1a+ cells after transcutaneous application on human skin”

Die Zielsetzung der „Fondation Internationale La Roche-Posay”, erstmals ausgeschrieben 1985, ist die Förderung Internationaler Forschungsarbeiten in der Dermatologie.

Die Preise der Fondation International LA ROCHE-POSAY Laboratoire Dermatologique 2004

wurden im Rahmen des Kongresses der EADV (European Academy of Dermatology and Venerologie) in Florenz vergeben

Die Zielsetzung der „Fondation Internationale La Roche-Posay", erstmals ausgeschrieben 1985, ist die Förderung Internationaler Forschungsarbeiten in der Dermatologie.

In diesem Jahr hat das Internationale wissenschaftliche Komitee unter dem Vorsitz von Prof. TAIEB (Frankreich) und den Mitgliedern Prof. GELMETTI (Italien), Prof. HANEKE (Deutschland), Prof de RAEVE (Belgien), Prof. GRIMALT (Spanien), Prof. BLACK (England), Pr LARREGUE (Frankreich), Prof. BIEBER (Deutschland) and Prof. LUGER (Deutschland)

3 Forscher für ihre Arbeit in der dermatologischen Forschung ausgezeichnet:

  • The Research Project Prize of 10 000 euros : To M. Carlo PINCELLI , Institute of Dermatology, University of Modena and Reggio Emilia, Italy
    For his work:

    "The role of the low-affinity p75 receptor in UV-induced keratinocyte and melanocyte apoptosis”
  • The Research Prize of 6 000 euros for already published research paper to M. Jean Pierre HACHEM, Vrige University, Brussels, Belgium
    For the following published work:

    "pH directly regulates epidermal permeability barrier homeostasis and stratum corneum integrity/cohesion.”
  • The Research Prize of 6 000 euros for already published clinical study paper to M. Jorge FRANK, Department of Dermatology and Allergology, University Clinic of RWTH Aachen, AACHEN, Germany
    For the following published work:

    "Type 2 segmental Hailey-Hailey disease originating from loss of heterozygosity: molecular confirmation on a novel genetic concept”

Die Preise der Fondation International LA ROCHE-POSAY Laboratoire Dermatologique 2003

wurden im Rahmen des Kongresses der EADV (European Academy of Dermatology and Venerologie) in Barcelona verkündet

  • The Research Project Prize of 10 000 euros: To M. Reinhard Dummer (University Hospital Zurich, Switzerland)
    For his work:

    "Replicating viruses in cutaneous neoplasms”
  • The Research Prize of 6 000 euros for research paper already published to M. Martin Leverkus (Universitäts-Hautklinik Würzburg)
    For the following published work:

    "Proteasome Inhibition results in TRAIL Sensitization of primary Keratinocytes by removing the Resistance-Mediating Block of Effector Caspase Maturation”
    Molecular and Cellular Biology, Feb 2003-11-13
  • A special jury Prize of 6 000 euros for research paper already published to M. Jin Ho Chung (Dept. Of Dermatology Seoul National University Hospital, Seoul, Korea)
    For the following published work:

    "Aging- and Photoaging-Dependent changes of enzymic and nonenzymic Antioxidants in the Epidermis and Dermis of human Skin in vivo”
    Journal of Investigative Dermatology 117:1212-1217, 2001

Communiqué

During the last EADV CONGRESS (European Academy of Dermatology and Venereology), in the prestigious Prague Congress Center in Prague, the ’’Fondation Internationale La Roche-Posay” Award Ceremony for the Year 2002 took place.

The purpose of the the ‘’Fondation Internationale La Roche-Posay’’ established in 1985, is to encourage and reward international research work (other than French) in Dermatology.

This year, the International Scientific Committee chaired by Pr Larrègue (France) and composed of Pr Gelmetti (Italy), Pr Haneke (Norway), Pr de RAEVE (Belgium), Pr Grimalt (Spain), Pr BLACK (England), Pr Taieb (France), Pr Bieber (Germany) and Pr Luger (Germany), awarded 2 researchers and their work for their contribution to dermatological research

The 2 following prizes were presented by Professor Larrègue (France):

  • The Research Project Prize of 8 000 euros:
    To M. Kevin John MCELWEE (Germany)
    For his work:

    The association of CD4+/CD25+ cell deficiency with alopecia areata in humans and the C3H/HeJ model.
  • The Research Prize of 8 000 euros for research paper already published
    To Ms. Selma UGUREL (Germany)
    For the following published works:

    Soluble Human Leukocyte Antigen-G Serum Level is elevated in Melanoma Patients and is further increased by Interferon-Immunotherapy
    Clinical Cancer 92 : 369-376

    Increased Soluble CD95 (sFas/CD95) Serum Level Correlates with Poor Prognosis in Melanoma patients
    Clinical Cancer Research vol 7 : 1282-1286, may 2001.

    Increased Serum Concentration of Angiogenic Factors in malignant melanoma Patients Correlates with Tumor Progression and Survival.
    Journal of Clinical Oncology : Vol 19, n°2 (January 15), 2001 : pp 577-583.

Die Preise der Fondation International LA ROCHE-POSAY Laboratoire Dermatologie 2001

wurden im Rahmen des Kongresses der EADV (European Academy of Dermatology and Venerologie) in München überreicht

  • The Research Project Prize of FF 50.000
    Andreas Ambach, Bernd Bonnekoh, Harald Gollnick,
    Otto-von-Guericke-Universität Magdeburg für die Arbeit: "Perforin Hyperreleasability and Depletion in Cytotoxic T Cells of Patients Affected with Exacerbated Atopic Dermatitis and Asymptomatic Rhinoconjunctiviits Allergica".
  • The Clinical Research Prize of FF 15.000
    Hans Starz,
    Klinik für Dermatologie und Allergologie Augsburg für seine Arbeit: "A Micromorphometry-Based concept for routine classification of Sentinel Lymph Node Metastases and its Clinical Relevance for Patients with Melanoma".
  • The Biological Research Prize of FF 15.000:
    Claudia Traidl-Hoffmann
    , Zentrum Allergie und Umwelt an der Klinik und Poliklinik für Dermatologie und Allergologie München für ihre Arbeit: "Desparate Cyototoxic Activity of Nickel-Specific CD8+ and CD4+ Cell subsets against Keratinocytes".
  • The Pharmacological Research Prize of FF 15.000:
    Christoph Schempp
    , Universitäts-Hautklinik Freiburg für seine Arbeit: "Magnesium ions inhibit the antigenpresenting function of human epidermal Langerhans Cells in vivo and in vitro".

Die Gewinner

Gewinner 2000

During the last EADV CONGRESS ( European Academy of Dermatology and Venereology), in the prestigious Victoria Hall in Geneva, The "Fondation Internationale La Roche-Posay" Award Ceremony for the Year 2000 took place.

The 4 following prizes were presented by Pr. Taeb:

  • The Research Project Prize of 50 000 FF:
    To Mr. Peter Wolf (Austria)
    For his work:
    "Ha-ras protooncogene mutation analysis in skin cancers of psoralens + UVA (PUVA)-treated patients".
  • The Clinical Research Prize of 15 000 FF:
    To Mrs. Garnet Vancoillie and col. (Belgium)
    For her work:
    "Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes".
  • The Biological Research Prize of 15 000 FF:
    To Mr. Martin Steinhoff and col. (Germany)
    For his work:
    "Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism" and "New feelings about the role of sensory nerves in inflammation".
  • The Pharmacological Research Prize of 15 000 FF:
    To Mr. Hamm-ming Sheu and col. (Taiwan)
    For his work:
    "Human skin surface lipid film: an ultrastructural study and interaction with corneocytes and intracellular lipid lamellae of the stratum corneum".